Search results for "Type I interferons"

showing 2 items of 2 documents

Type I interferons as the potential mechanism linking mRNA COVID-19 vaccines to Bell's palsy

2021

Therapies - Sous presse. Epreuves corrigees par l'auteur. Disponible en ligne depuis le mardi 13 avril 2021

AdultMale2019-20 coronavirus outbreakCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)COVID-19 vaccines030226 pharmacology & pharmacyArticle03 medical and health sciencesPharmacovigilance0302 clinical medicineBell's palsyPhase 3 clinical trialsBell PalsymedicineType I interferonsHumansBell's palsyPharmacology (medical)Potential mechanismComputingMilieux_MISCELLANEOUSAgedCOVID-19 coronavirus disease 2019Vaccines SyntheticMessenger RNASARS-CoV-2business.industryCOVID-19Bell’s palsyMiddle Agedmedicine.diseaseVirologymRNA messenger RNA3. Good healthInterferon Type IFemale[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologiebusiness
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Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells

2019

Summary Environmental signals shape host physiology and fitness. Microbiota-derived cues are required to program conventional dendritic cells (cDCs) during the steady state so that they can promptly respond and initiate adaptive immune responses when encountering pathogens. However, the molecular underpinnings of microbiota-guided instructive programs are not well understood. Here, we report that the indigenous microbiota controls constitutive production of type I interferons (IFN-I) by plasmacytoid DCs. Using genome-wide analysis of transcriptional and epigenetic regulomes of cDCs from germ-free and IFN-I receptor (IFNAR)-deficient mice, we found that tonic IFNAR signaling instructs a spec…

MaleReceptor Interferon alpha-betaAdaptive ImmunityCD8-Positive T-LymphocytesBiologyGeneral Biochemistry Genetics and Molecular BiologyMice03 medical and health sciences0302 clinical medicineImmune systemAntigenAnimalsEpigeneticsReceptor030304 developmental biologyEpigenomics0303 health sciencesMicrobiotaPeripheral toleranceDendritic Cellsperipheral toleranceCell biologyMice Inbred C57BLtype I interferonsplasmacytoid dendritic cellsconventional dendritic cellsInterferon Type IFemale030217 neurology & neurosurgerySignal TransductionCell
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